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FACTOR XII
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DeCS
Descriptor
English
:
Factor XII
Descriptor
Spanish
:
Factor XII
Descriptor
Portuguese
:
Fator XII
Synonyms
English
:
Hageman Factor
Coagulation Factor XII
Tree Number:
D12.776.124.125.450
D23.119.450
Definition
English
:
Stable
blood coagulation
factor activated by contact with the subendothelial surface of an injured vessel. Along with
prekallikrein
, it serves as the contact factor that initiates the intrinsic pathway of
blood coagulation
. Kallikrein activates
factor XII
to XIIa. Deficiency of
factor XII
, also called the Hageman trait, leads to increased
incidence
of thromboembolic
disease
.
Mutations
in the gene for
factor XII
that appear to increase
factor XII
amidolytic activity are associated with
HEREDITARY ANGIOEDEMA TYPE III.
Entry Combination - descr/qualif
English
:
Factor XII
/
deficiency
use
Factor XII Deficiency
See Related
English
:
Coagulants
Hereditary Angioedema Type III
History Note
English
:
66(64)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22175
Unique Identifier:
D005174
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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